Institute for Frontier Medical Sciences, Kyoto University
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Divisions and Departments
Field of Biological Function
Field of Tissue Engineering
Department of Cellular Differentiation
Department of Biomaterials
Department of Reparative Materials
Depatment of Mechanical Properties
Field of Tissue Engineering
Field of Clinical Application
Field of Stem Cell Research
Adjunct Facilities
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Kyoto University
 
Field of Tissue Engineering
 
Department of Cellular Differentiation | Department of Biomaterials |
Department of Reparative Materials
Department of Cellular Differentiation

Prof. Yuji Hiraki
Prof. Chisa Shukunami

We are aiming at the elucidation of molecular interactions and signaling networks underlying bone and cartilage formation. Our current research efforts are focused on the following studies: (1) Action mechanisms of cartilage-specific growth modulating factor chondromodulin-I and tendon-specific angiogenesis inhibitor tenomodulin; (2) Regulatory mechanism of endochondral bone formation; (3) Transcriptional regulation of tenomodulin gene; (4) Identification of regulatory genes associated with chondrogenic differentiation; (5) Action mechanisms of tissue-specific anti-angiogenic factors (chondromodulin-I & tenomodulin) and its therapeutic applications for angiogenic diseases.

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Department of Biomaterials

Prof. Yasuhiko Tabata
Assoc. Prof. Masaya Yamamoto

The main objective of our department is to proceed the research and development of methods, procedures, and technologies applicable to biology or basic and clinical medicines from the viewpoint of material sciences. The materials to use in the body and to directly contact biological substances are defined as biomaterials. We are designing and synthesizing various types of biodegradable or non-biodegradable biomaterials. Our research goal is not only to positively carry out basic researches of biomaterial-based tissue engineering, drug delivery system (DDS), biomedical engineering, and stem cell technology but also put the research results to clinical and practical uses.

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Department of Reparative Materials

Prof. Hiroo Iwata
Assist. Prof. Yusuke Arima

We implement materials engineering approaches to overcome problems associated with current technology for cellbased therapy, namely for diabetic milieu and central nervous disorders, focusing on the followings: 1) Constructing artificial environments that promote differentiation of embryonic and somatic stem cells into functional cells, taking advantage of biological interactions of cells with extracellular matrices, growth factors, and stromal cells. 2) Tailoring semi-permeable membranes for use in immunoisolation of transplanted cells in the recipient. Engineered protein-based materials are further designed for facilitating the engraftment of transplanted cells and the efficient reconstruction of tissues. 3) Gaining deeper insights into the molecular events taking place at the interface between artificial materials and biological systems, by means of surface-sensitive analytical techniques. 4) Establishing the high-throughput assay technology that allows cell-based functional screening for biomolecules having significant impacts on the physiology of stem cells.

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