Institute for Frontier Medical Sciences, Kyoto University
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Divisions and Departments
Field of Biological Function
Department of Molecular and Cellular Biology
Department of Ultrastructural Research
Department of Experimental Pathology
Department of Medical Systems Control
Field of Tissue Engineering
Field of Tissue Engineering
Field of Clinical Application
Field of Stem Cell Research
Adjunct Facilities
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Kyoto University
 
Field of Biological Function
 
Department of Molecular and Cellular Biology | Department of Experimental Pathology |
Department of Medical Systems Control
Department of Molecular and Cellular Biology

Assoc. Prof. Nobuko Hosokawa
Assoc. Prof. Masayuki Yamasaki
Lect. Kazunori Hirayoshi
Assist. Prof. Shinji Fujimoto

1) Newly synthesized proteins obtain their native conformations by the assistance of molecular chaperones and folding enzymes, whereas terminally misfolded proteins are degraded within the cells. This cellular function is called as the quality control mechanism of proteins. (Nobuko Hosokawa)
2) We focus on the analysis of a) Gene specific transcription complex, b) Chromatin remodeling related factors in the transcription complex with RNA aptamers. (Kazunori Hirayoshi)
3) We have tried to reveal how TCR beta gene rearrangement proceeds by analyzing TCR beta locus of a lot of murine thymic lymphomas. In vivo generation of T cells expressing two kinds of TCR beta molecules is largely inhibited. However, we have shown that the regulation is not so strict at the level of gene rearrangement. (Shinji Fujimoto)

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Department of Experimental Pathology

Prof. Shimon Sakaguchi
Assist. Prof. Yoshinaga Ito

We are studying (i) the cellular and molecular basis of immunologic self-tolerance and autoimmune disease as its abnormality ; (ii) the strategy for eliciting effective immune responses to autologous tumor cells or inducing acceptance of organ transplants by manipulating the mechanism of immunologic selftolerance ; and (iii) the cause and pathogenetic mechanism of rheumatoid arthritis by analyzing a newly established mouse model of autoimmune arthritis.

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Department of Medical Systems Control

Prof. Takashi Nagasawa
Assist. Prof. Tatsuki Sugiyama
Assist. Prof. Yoshiki Omatsu

Chemokines are structurally related small chemoattractive cytokines. We isolated a chemokine, CXCL12 (SDF-1/ PBSF) as a molecule that stimulates the growth of B lymphocyte precursors and have found its multiple physiological functions in development. We have shown that the primary physiologic receptor for CXCL12 is CXCR4, which also functions as a coreceptor for strains of HIV-1 and that CXCL12-CXCR4 signaling is essential for colonization of bone marrow by hematopoietic cells including hematopoietic stem cells (HSCs), colonization of gonads by primordial germ cells (PGCs) during ontogeny, maintenance of a pool of HSCs in adult bone marrow, development of B lymphocytes, vascularization of the gastrointestinal tract and cardiogenesis. In recent years, we have identified a population of reticular cells, which express CXCL12 at high levels, termed CXCL12 abundant reticular (CAR) cells within bone marrow and suggested that CAR cells function as the special microenvironment niches for HSCs and B lymphocytes and that CXCL12 maintains the stem cells or precursors in the niche. We are studying the roles of CXCL12-CXCR4 signaling and CAR cells in hematopoiesis to understand the spatiotemporal regulation of lymphohematopoiesis by environmental factors within bone marrow.

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